Giles Michelle, Garland Suzanne
Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Carlton, Victoria, Australia.
Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):180-5. doi: 10.1111/j.1479-828X.2006.00580.x.
Human papillomavirus (HPV) infection is common and causes a wide spectrum of disease. With recent advances in the development of prophylactic HPV vaccines, it is likely that these will be licensed for use in the near future. This review focuses on the science behind HPV vaccines, published clinical trial results for both prophylactic and therapeutic HPV vaccines, important issues relevant to implementation and cost-effectiveness models of HPV vaccination programs. It may be that an HPV vaccine that protects against the complications of HPV infection such as cervical cancer will be one of the most significant public health initiatives of this decade.
人乳头瘤病毒（HPV）感染很常见，可引发多种疾病。随着预防性HPV疫苗研发的最新进展，这些疫苗很可能在不久的将来获得许可投入使用。本综述重点关注HPV疫苗背后的科学原理、预防性和治疗性HPV疫苗已发表的临床试验结果、与HPV疫苗接种计划实施相关的重要问题以及成本效益模型。预防HPV感染并发症（如宫颈癌）的HPV疫苗可能会成为这十年最重要的公共卫生举措之一。
