Goodyear-Smith Felicity, Knowles Alison, Masters Jonathan
Auckland Medical Aid Centre, Mt. Eden, Auckland, New Zealand.
Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):193-8. doi: 10.1111/j.1479-828X.2006.00575.x.
First trimester medical terminations of pregnancy (TOP) have been carried out in a private abortion clinic in Auckland from 1 July 2003 to 30 June 2005.
To audit first trimester medical TOP outcomes over the first 2 years and to compare the demographics and complication rates of women opting for medical TOP with those choosing surgical TOP during this period.
Retrospective, consecutive case audit of women presenting for a first trimester TOP. Anonymous audit included ethnicity, gestation at first appointment, pain relief requirements, blood loss, timing from the taking of misoprostol to expulsion of products of conception, complications and comparison of outcomes and characteristics between medical termination of pregnancy (MTOP) and surgical termination of pregnancy (STOP).
A total of 3311 TOPs were performed over the 2-year study period, including 390 MTOPs (12%). No significant differences were found in age, ethnicity or history of previous TOP between women choosing MTOP or STOP. Gravida 1 and nulliparous women were significantly more likely to choose MTOP. Five per cent (21/390) of women taking mifepristone progressed to STOP. Complications involving hospitalisation occurred in six MTOPs (1.5%) and 18 STOPs (0.6%).
First trimester MTOP is safe and effective and is a realistic alternative for women wanting choice of method in New Zealand.
2003年7月1日至2005年6月30日期间，奥克兰一家私人堕胎诊所进行了孕早期药物流产。
对头两年的孕早期药物流产结果进行审核，并比较在此期间选择药物流产的女性与选择手术流产的女性的人口统计学特征和并发症发生率。
对前来进行孕早期流产的女性进行回顾性连续病例审核。匿名审核内容包括种族、首次就诊时的孕周、止痛需求、失血量、从服用米索前列醇到排出妊娠产物的时间、并发症以及药物流产（MTOP）和手术流产（STOP）之间的结果和特征比较。
在为期两年的研究期间，共进行了3311例流产，其中包括390例药物流产（12%）。选择药物流产或手术流产的女性在年龄、种族或既往流产史方面未发现显著差异。初产妇和未生育女性明显更倾向于选择药物流产。服用米非司酮的女性中有5%（21/390）转为手术流产。药物流产中有6例（1.5%）和手术流产中有18例（0.6%）出现了需要住院治疗的并发症。
孕早期药物流产安全有效，对于希望在新西兰选择流产方式的女性来说是一种切实可行的选择。
