Roa Juan Carlos, Tapia Oscar, Carrasco Paula, Contreras Enrique, Araya Juan Carlos, Muñoz Sergio, Roa Iván
Department of Pathology, Universidad de la Frontera, Temuco, Chile.
Pathol Int. 2006 Jun;56(6):309-14. doi: 10.1111/j.1440-1827.2006.01965.x.
The phyllodes tumor is characterized by its tendency to recur locally and occasionally to metastasize. The purpose of the present paper was to assess the prognostic value of clinical-morphological characteristics in patients with phyllodes tumor. Forty-seven cases of phyllodes tumors was studied; the World Health Organization classification was used and follow up was obtained. A total of 51%, 28% and 21% of the tumors were classified as benign, borderline and malignant, respectively. The adherence (P = 0.01), size >10 cm (P = 0.001), high mitotic activity (P = 0.03), infiltrative tumor margin (P = 0.0002) and type of surgery in malignant tumors (P = 0.02) proved to be good predictors of relapse. The presence of pain (P = 0.03), postmenopausal status (P < 0.04), heavy cellular pleomorphism (P = 0.007), high mitotic activity (P = 0.002), tumoral grade (P = 0.006) and metastasis (P < 0.00001) were prognostic factors of poor survival. Tumoral grade and some clinical-morphological characteristics of patients with phyllodes tumors have a significant impact on the prediction of its biological behavior.
叶状肿瘤的特点是易于局部复发，偶尔发生转移。本文旨在评估叶状肿瘤患者临床形态学特征的预后价值。研究了47例叶状肿瘤病例；采用世界卫生组织分类法并进行随访。分别有51%、28%和21%的肿瘤被分类为良性、交界性和恶性。肿瘤粘连（P = 0.01）、大小>10 cm（P = 0.001）、高有丝分裂活性（P = 0.03）、浸润性肿瘤边缘（P = 0.0002）以及恶性肿瘤的手术类型（P = 0.02）被证明是复发的良好预测指标。疼痛的存在（P = 0.03）、绝经后状态（P < 0.04）、重度细胞多形性（P = 0.007）、高有丝分裂活性（P = 0.002）、肿瘤分级（P = 0.006）和转移（P < 0.00001）是生存不良的预后因素。肿瘤分级以及叶状肿瘤患者的一些临床形态学特征对其生物学行为的预测有显著影响。
