Myint Kyaw, Armbrecht Ana Maria, Mon Sue, Dhillon Baljean
Princess Alexandra Eye Pavilion, Edinburgh, UK.
Acta Ophthalmol Scand. 2006 Jun;84(3):328-32. doi: 10.1111/j.1600-0420.2005.00623.x.
To evaluate whether transpupillary thermotherapy (TTT) reduces the risk of moderate visual loss in patients with occult choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).
A group of 25 patients were recruited and randomized into TTT or placebo groups. Patients were included if they had a subfoveal purely or predominantly (> 50%) occult CNV secondary to AMD with best corrected visual acuity (BCVA) of 6/60 or better and the lesion was not larger than 4.5 mm. Treatment was carried out using an 810-nm Oculight diode laser with a fixed spot size covering the whole lesion according to the standard protocol. The same procedure was used for the control group, except that the power was set at zero. The patients were followed up at 6 weeks, 3 months and then every 6 months for up to 2 years. A maximum of three treatments were administered in both groups if there was evidence of persistent leakage from CNV.
At the 12-month follow-up, there was no significant difference in the mean values for BCVA distance and near or contrast sensitivity between the treatment and control groups. The Mann-Whitney test was used to assess the differences in BCVA and contrast sensitivity between the groups, both at baseline and at the 12-month follow-up. No statistically significant difference was found; both groups lost on average two lines of BCVA.
Transpupillary thermotherapy appeared to have been of no benefit in preventing further visual loss in patients with occult CNV in this pilot study.
评估经瞳孔温热疗法（TTT）是否能降低年龄相关性黄斑变性（AMD）继发隐匿性脉络膜新生血管（CNV）患者中度视力丧失的风险。
招募25名患者并随机分为TTT组或安慰剂组。纳入标准为患有AMD继发的黄斑中心凹下单纯性或主要为（>50%）隐匿性CNV，最佳矫正视力（BCVA）为6/60或更好，且病变不大于4.5mm。根据标准方案，使用810nm的Oculight二极管激光进行治疗，固定光斑大小覆盖整个病变。对照组采用相同程序，但功率设置为零。患者在6周、3个月时进行随访，之后每6个月随访一次，最长随访2年。如果有CNV持续渗漏的证据，两组最多进行三次治疗。
在12个月的随访中，治疗组和对照组在BCVA远视力、近视力或对比敏感度的平均值上没有显著差异。采用Mann-Whitney检验评估两组在基线和12个月随访时BCVA和对比敏感度的差异。未发现统计学上的显著差异；两组平均BCVA均下降了两行。
在这项初步研究中，经瞳孔温热疗法似乎对预防隐匿性CNV患者的进一步视力丧失没有益处。
