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变异型克雅氏病小鼠淋巴网状肿瘤中的蛋白酶抗性朊病毒蛋白

Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice.

作者信息

Cervenakova Larisa, Yakovleva Oksana, McKenzie Carroll

机构信息

Transmissible Diseases Department, J.H. Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA.

出版信息

Emerg Infect Dis. 2006 Mar;12(3):511-3. doi: 10.3201/eid1205.051348.

DOI:10.3201/eid1205.051348
PMID:16704797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3291462/
Abstract

We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrPres may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms.

摘要

我们报告了在感染变异型克雅氏病（vCJD）病原体的小鼠自发淋巴网状肿瘤中存在蛋白酶抗性朊病毒蛋白（PrPres）。PrPres可能在无症状vCJD患者的淋巴网状系统肿瘤中蓄积。通过扩大筛查范围以纳入淋巴网状肿瘤样本，vCJD患病率估计的统计效力可能会提高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c084/3291462/30e4034dade7/05-1348-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c084/3291462/30e4034dade7/05-1348-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c084/3291462/30e4034dade7/05-1348-F.jpg

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本文引用的文献

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PrPSc in mammary glands of sheep affected by scrapie and mastitis.感染羊瘙痒病和乳腺炎的绵羊乳腺中的朊病毒蛋白（PrPSc）
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变异型克雅氏病病原体在具有间充质干细胞特征的小鼠脾基质细胞培养物中的持续增殖。
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Prevalence of lymphoreticular prion protein accumulation in UK tissue samples.英国组织样本中淋巴网状朊蛋白积累的患病率。
J Pathol. 2004 Jul;203(3):733-9. doi: 10.1002/path.1580.
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Standards for the assay of Creutzfeldt-Jakob disease specimens.克雅氏病标本检测标准。
J Gen Virol. 2004 Jun;85(Pt 6):1777-1784. doi: 10.1099/vir.0.79959-0.
7
Specificity of lymphoreticular accumulation of prion protein for variant Creutzfeldt-Jakob disease.朊蛋白在淋巴网状组织中聚集对变异型克雅氏病的特异性。
J Clin Pathol. 2004 Mar;57(3):300-2. doi: 10.1136/jcp.2003.012278.
8
Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy.感染人类来源的变异型克雅氏病（vCJD）和格斯特曼综合征（GSS）可传播性海绵状脑病毒株的小鼠血液中，传染性水平相似。
Transfusion. 2003 Dec;43(12):1687-94. doi: 10.1046/j.0041-1132.2003.00586.x.
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