Bakuridze K A, Gongadze N V
Georgian Med News. 2006 Apr(133):120-4.
Effect of moxonidine on hemodynamic parameters, baroreflex sensitivity (BS) and sympatho-adrenal system was studied on the model of emotional stress in normotensive (N) and hypertensive (H) rats. Moxonidine was administered intravenously in daily dose 100 mcg/kg during one week prior to stress condition. It was shown that moxonidine reduced pressor reactions of arterial pressure, tachycardia and have increased BS especially in H animals, which was blunted during aversive stimulation. Moxonidine also revealed the effect of pharmacological correction of catecholamine - norepinephrine and epinephrine content in the myocardium and adrenals in stress and post stress period more markedly in H rats. The data obtained indicate the preventive antistress activity of the moxonidine.
在正常血压（N）和高血压（H）大鼠的情绪应激模型上，研究了莫索尼定对血流动力学参数、压力反射敏感性（BS）和交感 - 肾上腺系统的影响。在应激状态前一周，以每日100 mcg/kg的剂量静脉注射莫索尼定。结果表明，莫索尼定可降低动脉血压的升压反应、心动过速，尤其在H组动物中可提高压力反射敏感性，而在厌恶刺激期间该敏感性会减弱。莫索尼定还更明显地显示出在应激期和应激后阶段对H组大鼠心肌和肾上腺中儿茶酚胺 - 去甲肾上腺素和肾上腺素含量进行药理学纠正的作用。所获得的数据表明莫索尼定具有预防性抗应激活性。
