Noz Marilyn E, Chung Grace, Lee Benjamin Y, Maguire Gerald Q, DeWyngaert J Keith, Doshi Jay V, Kramer Elissa L, Murphy-Walcott Antoinette D, Zeleznik Michael P, Kwak Noeun G
Department of Radiology, NYU School of Medicine, New York, USA.
J Med Syst. 2006 Apr;30(2):123-32. doi: 10.1007/s10916-005-7987-y.
This project investigated reducing the artifact content of In-ill ProstaScint SPECT scans for use in treatment planning and management. Forty-one patients who had undergone CT or MRI scans and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans were included. SPECT volume sets, reconstructed using Ordered Set-Expectation Maximum (OS-EM) were compared against those reconstructed with standard Filtered Back projection (FBP). Bladder activity in Tc-99m scans was suppressed within an ellipsoidal volume. Tc-99m voxel values were subtracted from the corresponding In-111 after scaling based on peak activity within the descending aorta. The SPECT volume data sets were merged with the CT or MRI scans before and after processing. Volume merging, based both on visual assessment and statistical evaluation, was not affected. Thus iterative reconstruction together with bladder suppression and blood pool subtraction may improve the interpretation and utility of ProstaScint SPECT scans for patient management.
本项目研究了减少用于治疗计划和管理的铟-111 前列腺闪烁单光子发射计算机断层扫描（SPECT）中的伪影含量。纳入了 41 例已接受 CT 或 MRI 扫描以及同时进行的锝-99m 红细胞/铟-111 前列腺闪烁 SPECT 扫描的患者。将使用有序子集期望最大化（OS-EM）重建的 SPECT 容积集与使用标准滤波反投影（FBP）重建的容积集进行比较。在椭圆形容积内抑制锝-99m 扫描中的膀胱活性。在基于降主动脉内的峰值活性进行缩放后，从相应的铟-111 中减去锝-99m 体素值。在处理前后，将 SPECT 容积数据集与 CT 或 MRI 扫描合并。基于视觉评估和统计评估的容积合并未受影响。因此，迭代重建以及膀胱抑制和血池减法可能会改善前列腺闪烁 SPECT 扫描在患者管理中的解读和效用。
