Guo Yingqiang, Shi Yingkan, Zhang Jianmin, Xue Weilin, Liu Shanjun
Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Apr;23(2):300-3.
For the defects of interpreting the relationship between the distribution and severity of vascular stenostic disease and the low shear stress, the study focus on and explore the rules of the pressure distribution and variation downstream of the stenostic vessel with the numerical simulation and the hydrodynamic model of turbulent flow separation area for in vitro experiment. The results reveal that there is a good compatibility between the model experiment and the numerical simulation; there exists a marked pressure decrease downstream of the stenosis. And the distribution area of low pressure is similar to the characteristic distribution of the stenostic vessel diseases. The study suggested that the numerical simulation can be applied in the study of micro-flow field; the presure distribution and variatioin downstream of the stenostic vessel maybe another factor to trigger the pathogenesis of vessel stenostic diseases.
针对在解释血管狭窄性疾病的分布与严重程度和低切应力之间关系方面存在的缺陷，本研究通过数值模拟以及体外实验的湍流分离区流体动力学模型，着重研究并探索狭窄血管下游的压力分布及变化规律。结果表明，模型实验与数值模拟具有良好的兼容性；狭窄下游存在明显的压力降低。并且低压分布区域与狭窄性血管疾病的特征分布相似。该研究表明，数值模拟可应用于微流场研究；狭窄血管下游的压力分布及变化可能是引发血管狭窄性疾病发病机制的另一个因素。
