Jin Yinbin, Yang Lin, Zhang Hong, Huang Yezhuo, Jiang Dazong
College of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Apr;23(2):419-23.
Computer simulation is one of the powerful protocols to study electrophysiology theoretically. In this paper,the algorithm of Rush and Larsen was used to solve the ordinary differential equations (ODE's) in the Luo-Rudy models of mammalian ventricular cell. The operator splitting and adaptive time step methods were used to solve the partial differential equations (PDE's) in cardiac tissue conduction models. Using these methods we accomplished the simulation programs of single ventricular cell model and two-dimensional (2-D) tissue model. The methods of initiating spiral waves were studied with this software. The data obtained from 2-D simulation can be used for further study on isopotential contour lines, spiral wave tip trajectories, and pseudo-ECG.
计算机模拟是从理论上研究电生理学的强大手段之一。在本文中，采用拉什和拉森算法求解哺乳动物心室细胞罗-鲁迪模型中的常微分方程（ODE）。运用算子分裂和自适应时间步长方法求解心脏组织传导模型中的偏微分方程（PDE）。利用这些方法，我们完成了单心室细胞模型和二维（2-D）组织模型的模拟程序。利用该软件研究了引发螺旋波的方法。二维模拟获得的数据可用于等电位轮廓线、螺旋波尖端轨迹和伪心电图的进一步研究。
