艾滋病中的促吞噬肽缺乏症。

Tuftsin deficiency in AIDS.

作者信息

Corazza G R, Zoli G, Ginaldi L, Cancellieri C, Profeta V, Gasbarrini G, Quaglino D

机构信息

Department of Medicine and Public Health, University of L'Aquila, Italy.

出版信息

Lancet. 1991 Jan 5;337(8732):12-3. doi: 10.1016/0140-6736(91)93331-3.

DOI:10.1016/0140-6736(91)93331-3

PMID:1670648

Abstract

Tuftsin is an endogenous tetrapeptide that stimulates phagocytosis and is released from the Fc fragment of IgG by a splenic endocarboxypeptidase. Tuftsin activity and splenic function were measured in 21 patients with AIDS, 7 patients with AIDS-related complex (ARC), 22 patients who had undergone splenectomy, and 37 healthy volunteers. There was a significant inverse correlation between tuftsin activity and splenic function in all subjects. Tuftsin activity was significantly lower in patients with AIDS, ARC, and in those who had undergone splenectomy compared with healthy volunteers. Tuftsin deficiency may contribute to the risk of bacterial infection in symptomatic HIV-positive individuals.

摘要

促吞噬肽是一种内源性四肽，可刺激吞噬作用，并由脾脏内羧肽酶从IgG的Fc片段释放。对21例艾滋病患者、7例艾滋病相关综合征（ARC）患者、22例接受脾切除术的患者和37名健康志愿者进行了促吞噬肽活性和脾脏功能的检测。在所有受试者中，促吞噬肽活性与脾脏功能之间存在显著的负相关。与健康志愿者相比，艾滋病患者、ARC患者以及接受脾切除术的患者的促吞噬肽活性显著降低。促吞噬肽缺乏可能导致有症状的HIV阳性个体发生细菌感染的风险增加。