碱性磷酸酶同工酶的研究。与γ-谷氨酰转移酶和乳酸脱氢酶同工酶的关系。

Studies on alkaline phosphatase isoenzymes. Relation to gamma-glutamyltransferase and lactate dehydrogenase isoenzymes.

作者信息

Brohult J, Fridell E, Sundblad L

出版信息

Clin Chim Acta. 1977 Apr 15;76(2):205-11. doi: 10.1016/0009-8981(77)90097-3.

Abstract

Gamma-Glutamyltransferase (GT) and isoenzymes of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) have been studied in 282 cases with increased S-ALP and in 18 chronic alcoholics with normal routine liver tests. There was a high degree of correlation between S-GT and the bile (alpha 1) and liver (alpha 2) fractions of S-ALP. Fractionation of alkaline phosphatases sometimes yielded clinical information, which could not be obtained by determinations of S-ALP and S-GT only. The presence of alpha 1-ALP and increased S-GT appeared to be more sensitive indicators of ethanol-induced liver involvement than other liver tests, including LDH-5/LDH-4 ratios.

摘要

对282例血清碱性磷酸酶（S-ALP）升高的患者以及18例常规肝功能检查正常的慢性酒精中毒患者，研究了γ-谷氨酰转移酶（GT）、碱性磷酸酶（ALP）同工酶和乳酸脱氢酶（LDH）。血清γ-谷氨酰转移酶（S-GT）与血清碱性磷酸酶（S-ALP）的胆汁（α1）和肝脏（α2）组分之间存在高度相关性。碱性磷酸酶的分级分离有时能提供仅通过测定S-ALP和S-GT无法获得的临床信息。α1-ALP的存在和S-GT升高似乎比其他肝功能检查（包括LDH-5/LDH-4比值）更能敏感地指示乙醇引起的肝脏病变。