p,p'-滴滴涕和狄氏剂对大口黑鲈基因表达模式改变的建模
Modeling of gene expression pattern alteration by p,p'-DDE and dieldrin in largemouth bass.
作者信息
Garcia-Reyero Natàlia, Barber David, Gross Timothy, Denslow Nancy
机构信息
Center for Environmental and Human Toxicology (CEHT), University of Florida, Gainesville, FL 32611, USA.
出版信息
Mar Environ Res. 2006 Jul;62 Suppl(Suppl):S415-9. doi: 10.1016/j.marenvres.2006.04.049. Epub 2006 Apr 18.
Abstract
In this study, largemouth bass (LMB) were subchronically exposed to p,p'-DDE or dieldrin in their diet to evaluate the effect of exposure on expression of genes involved in reproduction and steroid homeostasis. Using real-time PCR, we detected a different gene expression pattern for each OCP, suggesting that they each affect LMB in a different way. We also detected a different expression pattern among sexes, suggesting that sexes are affected differently by OCPs perhaps reflecting the different adaptive responses of each sex to dysregulation caused by OCP exposure.
摘要
在本研究中，大口黑鲈在其饮食中被亚慢性暴露于p,p'-滴滴涕或狄氏剂，以评估暴露对参与生殖和类固醇稳态的基因表达的影响。使用实时PCR，我们检测到每种有机氯农药有不同的基因表达模式，表明它们对大口黑鲈的影响方式不同。我们还在不同性别中检测到不同的表达模式，表明有机氯农药对不同性别的影响不同，这可能反映了每种性别对有机氯农药暴露引起的失调的不同适应性反应。
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