Chang Hong, Yi Qi Long
Department of Laboratory Hematology, Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, 610 University Avenue 4-320, Toronto, Ontario, Canada.
Am J Clin Pathol. 2006 May;125(5):791-4. doi: 10.1309/93VF-M8CY-06KE-6FD6.
Acute myeloid leukemia (AML) with pseudo-Chèdiak-Higashi (PCH) anomaly is a rare morphologic entity. We characterized 5 cases by multiparameter flow cytometry and found that in all cases, the blasts aberrantly expressed CD2, a pan-T cell-associated marker, in addition to their myeloid-associated markers. In contrast, CD2 was expressed in only 25 (17.9%) of 140 cases of newly diagnosed AML without PCH anomaly. CD2 expression correlated strongly with AML with PCH anomaly (P < .01), suggesting a link between a specific immunophenotypic marker, CD2, and AML with PCH anomaly.
伴有假性柴-希二氏（PCH）异常的急性髓系白血病（AML）是一种罕见的形态学实体。我们通过多参数流式细胞术对5例病例进行了特征分析，发现所有病例中的原始细胞除了表达髓系相关标志物外，还异常表达CD2，一种泛T细胞相关标志物。相比之下，在140例新诊断的无PCH异常的AML病例中，只有25例（17.9%）表达CD2。CD2表达与伴有PCH异常的AML密切相关（P <.01），提示特定免疫表型标志物CD2与伴有PCH异常的AML之间存在联系。
