Vasconcelos C C F, Miranda-Santos C M, Alvarenga R M P
Pós-graduação em Neurologia da Universidade Federal Fluminense, Rio de Janeiro, Brazil.
Neuroepidemiology. 2006;26(4):233-9. doi: 10.1159/000093379. Epub 2006 May 16.
To describe the clinical course and outcome of multiple sclerosis with progressive onset in Brazilian patients. A total of 238 medical records were reviewed, 26 cases (10.9%) fulfilled Thompson criteria (2000), and 5.80% classified as primary progressive and 5.04% relapsing progressive according to Lublin and Reingold.
19 Caucasians and 7 non-Caucasians; male:female ratio 1.2:1, mean age at onset was 34 +/- 7.9 years.
Non-Caucasian patients had earlier onset of disease. The most common manifestations at onset were pyramidal and cerebellar (89% and 34.6%). After 11.3 +/- 6.35 years of disease more than 50% of the patients had involvement of most of their functional systems. No statistically significant differences were observed between the subgroups.
The clinical course and outcome of progressive multiple sclerosis in Brazil, a tropical country with low prevalence, were very similar to those in the multiple sclerosis high prevalence areas.
描述巴西患者中渐进性起病的多发性硬化症的临床病程及转归。共查阅了238份病历，26例（10.9%）符合汤普森标准（2000年），根据卢布林和赖因戈尔德的标准，5.80%归类为原发性进展型，5.04%为复发-进展型。
19名白种人和7名非白种人；男女比例为1.2:1，发病时的平均年龄为34±7.9岁。
非白种人患者发病更早。发病时最常见的表现为锥体束征和小脑征（分别为89%和34.6%）。病程11.3±6.35年后，超过50%的患者多数功能系统受累。各亚组之间未观察到统计学上的显著差异。
在患病率较低的热带国家巴西，进展型多发性硬化症的临床病程及转归与多发性硬化症高患病率地区非常相似。
Zotero 插件