Wasay M, Ali S, Khatri I A, Hassan A, Asif M, Zakiullah N, Ahmed A, Malik A, Khealani B, Haq A, Fredrikson S
The Aga Khan University, and Liaquat National Hospital, Karachi, Pakistan.
Mult Scler. 2007 Jun;13(5):668-9. doi: 10.1177/1352458506072339. Epub 2007 Feb 9.
We describe retrospective data from the largest series of patients (n=142) with multiple sclerosis (MS) from Pakistan. Mean age at onset was 27 years, with a female to male ratio of 1.45:1. The disease onset was polysymptomatic in 75% patients. Motor weakness was the most common onset symptom (70%), followed by sensory symptoms (45%). Optico-spinal type of MS was seen in only 3% of patients The course was relapsing-remitting (RR) in 81%, primary progressive (PP) in 21%, and secondary progressive (SP) in 4% of patients. Almost three-fourths of the patients were moderately (45%) or severely (31%) disabled at the time of evaluation. Two-thirds of patients with severe disability had a mean disease duration of only 5.2 years. In conclusion, MS is not uncommon in Pakistan, and many patients were found to have severe disability despite short disease duration.
我们描述了来自巴基斯坦最大系列的多发性硬化症（MS）患者（n = 142）的回顾性数据。发病时的平均年龄为27岁，女性与男性的比例为1.45:1。75%的患者发病时症状多样。运动无力是最常见的首发症状（70%），其次是感觉症状（45%）。仅3%的患者为视神经脊髓型MS。81%的患者病程为复发缓解型（RR），21%为原发进展型（PP），4%为继发进展型（SP）。在评估时，近四分之三的患者有中度（45%）或重度（31%）残疾。三分之二的重度残疾患者平均病程仅5.2年。总之，MS在巴基斯坦并不罕见，而且发现许多患者尽管病程短但仍有严重残疾。
