Gunstad John, Schofield Peter, Paul Robert H, Spitznagel Mary Beth, Cohen Ronald A, Williams Leanne M, Kohn Michael, Gordon Evian
Department of Psychology, Kent State University, Kent, Ohio, USA.
Neuropsychobiology. 2006;53(3):153-6. doi: 10.1159/000093341. Epub 2006 May 16.
Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 +/-3.77 vs. 24.72+/-4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship.
尽管最近的研究表明脑源性神经营养因子Val66Met多态性与饮食失调之间可能存在关联，但尚无研究探讨Met-Met基因型与健康个体较低体重指数（BMI）之间的可能性。我们在481名无重大医学或精神病史的成年人（年龄范围18 - 82岁）中研究了这种可能性。在对性别进行校正后，协方差分析显示，Met-Met基因型的人比Val-Met/Val-Val基因型的人BMI更低（分别为22.28±3.77和24.72±4.81）。分别比较所有三种基因型时也出现了类似趋势，尽管不显著。这些发现表明Val66Met多态性与健康成年人的BMI之间可能存在关联。需要进一步开展工作以阐明这种关联的可能机制。
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