Griac P, Holic R, Tahotna D
Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, Ivanka pri Dunaji, Slovakia.
Biochem Soc Trans. 2006 Jun;34(Pt 3):377-80. doi: 10.1042/BST0340377.
Yeast Sec14p acts as a phosphatidylinositol/phosphatidylcholine-transfer protein in vitro. In vivo, it is essential in promoting Golgi secretory function. Products of five genes named SFH1-SFH5 (Sec Fourteen Homologues 1-5) exhibit significant sequence homology to Sec14p and together they form the Sec14p family of lipid-transfer proteins. It is a diverse group of proteins with distinct subcellular localizations and varied physiological functions related to lipid metabolism and membrane trafficking.
酵母Sec14p在体外作为磷脂酰肌醇/磷脂酰胆碱转移蛋白发挥作用。在体内，它对于促进高尔基体分泌功能至关重要。名为SFH1 - SFH5（Sec十四同源物1 - 5）的五个基因的产物与Sec14p表现出显著的序列同源性，它们共同构成了脂质转移蛋白的Sec14p家族。这是一组多样的蛋白质，具有不同的亚细胞定位以及与脂质代谢和膜运输相关的多种生理功能。
