[癫痫发作与伐地那非]
[Epileptic seizures and vardenafil].
作者信息
Koussa S, Hage Chahine S, Tohmé A, Riachi M
机构信息
Service de Neurologie, Hôpital Hôtel-Dieu de France, Université Saint Joseph, Beyrouth, Liban.
出版信息
Rev Neurol (Paris). 2006 May;162(5):651-2. doi: 10.1016/s0035-3787(06)75062-7.
INTRODUCTION
Epileptic seizures complicating treatment with selective inhibitors of phosphodiesterase type 5 are scarcely reported.
CASE REPORT
A previously non-epileptic 78-year-old patient presented with a partial epileptic seizure following oral intake, for the second time, of 10mg of vardenafil (Levitra). The brain MRI failed to show any preexisting lesion. To our knowledge, only 2 cases of generalized tonic-clonic seizures induced by sildenafil (Viagra) use have been reported. In our patient, the seizure could be due to the epileptogenic potential of the drug or to its vascular complications.
CONCLUSION
Further studies are needed to elucidate the association of phosphodiesterase inhibitors use and epileptic seizures.
引言
关于5型磷酸二酯酶选择性抑制剂治疗引发癫痫发作的报道极少。
病例报告
一名既往无癫痫病史的78岁患者，在第二次口服10毫克伐地那非（艾力达）后出现部分性癫痫发作。脑部磁共振成像未显示任何既往病变。据我们所知，仅有2例使用西地那非（伟哥）诱发全身性强直阵挛发作的病例报道。在我们的患者中，癫痫发作可能是由于药物的致痫潜力或其血管并发症。
结论
需要进一步研究以阐明磷酸二酯酶抑制剂的使用与癫痫发作之间的关联。
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