Saiz Leonor, Vilar Jose M G
Integrative Biological Modeling Laboratory, Computational Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10021, USA.
Curr Opin Struct Biol. 2006 Jun;16(3):344-50. doi: 10.1016/j.sbi.2006.05.008. Epub 2006 May 22.
The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination and replication. Recently, advances have been made in understanding the properties of DNA looping in its natural context and how they propagate to cellular behavior through gene regulation. The result of connecting the molecular properties of DNA looping with cellular physiology measurements indicates that looping of DNA in vivo is much more complex and easier than predicted from current models, and reveals a wealth of previously unappreciated details.
蛋白质和蛋白质复合物形成DNA环的现象在许多基本细胞过程中普遍存在，包括转录、重组和复制。最近，在理解DNA环在其自然环境中的特性以及它们如何通过基因调控影响细胞行为方面取得了进展。将DNA环的分子特性与细胞生理学测量结果联系起来的结果表明，体内DNA环化比当前模型预测的要复杂得多且更容易，并且揭示了许多以前未被认识到的细节。
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