Kumar A P, Hustu O, Fleming I D, Wrenn E L, Pratt C B, Johnson W, Pinkel D
J Pediatr Surg. 1975 Jun;10(3):301-9. doi: 10.1016/0022-3468(75)90092-5.
The influence of capsular and vascular invasion on prognosis was determined retrospectively in 52 children with Wilms' tumor. Local recurrence was more prevalent (0.26) in patients with rupture or capsular invasion than in any other group. Inadequate postnephrectomy irradiation or infiltration of the liver by nephroblastoma cells appeared to be predisposing factors in the development of these reccurrences. Of the 26 patients with gross or microscopic vascular invasion, 13 developed metastasis. This proportion was significantly higher than in patients without vascular involvement (p less than 0.05). These observations emphasize the importance of microscopic detection of capsular and vascular invasion in staging of Wilm's tumor.
对52例肾母细胞瘤患儿进行回顾性研究，以确定包膜和血管侵犯对预后的影响。包膜破裂或受侵犯的患者局部复发更为常见（0.26），高于其他任何组。肾切除术后放疗不足或肾母细胞瘤细胞浸润肝脏似乎是这些复发的诱发因素。在26例有大体或显微镜下血管侵犯的患者中，13例发生转移。这一比例显著高于无血管受累的患者（p<0.05）。这些观察结果强调了在肾母细胞瘤分期中显微镜下检测包膜和血管侵犯的重要性。
