Kishi K, Yoshimasu T, Shirai S, Minakata Y, Kimura M, Sonomura T, Shioyama Y, Sato M
Department of Radiology, Wakayama Medical University, Wakayama City, Japan.
Br J Radiol. 2006 Jun;79(942):522-5. doi: 10.1259/bjr/31613651.
Endobronchial brachytherapy was developed as effective treatment of endobronchial cancer and fractionated schedule is applied to decrease late toxicity. However, repeated bronchofiberscopy is onerous to the patient and restricts the treatment schedule itself. We applied mini-tracheostomy for a ready access route, and a torque controlled technique for easy insertion of the endobronchial applicator. Eight patients with tracheobronchial cancer invasion were treated with endobronchial brachytherapy of 18-30 Gy/3-5 fractions/1.5-2.5 weeks (median 24 Gy/4 fractions/2 weeks) at reference points of 5 mm from the bronchial surface. The averaged individual irradiation and single session times were 4 min and 24 min, respectively. There were no procedure-related complications. These technical improvements may facilitate flexible fractionated dose prescriptions.
支气管内近距离放射治疗被开发用于治疗支气管内癌症,采用分次治疗方案以降低晚期毒性。然而,重复的支气管纤维镜检查对患者来说很麻烦,并且限制了治疗方案本身。我们采用微型气管造口术作为便捷的通路,并采用扭矩控制技术以便于插入支气管内施源器。8例气管支气管癌浸润患者接受了支气管内近距离放射治疗,剂量为18 - 30 Gy/3 - 5次/1.5 - 2.5周(中位值24 Gy/4次/2周),参考点距支气管表面5 mm。平均个体照射时间和单次治疗时间分别为4分钟和24分钟。未出现与操作相关的并发症。这些技术改进可能有助于灵活的分次剂量处方。