活细胞中组蛋白H1迁移率和染色质结合的决定因素。
Determinants of histone H1 mobility and chromatin binding in living cells.
作者信息
Catez Frédéric, Ueda Tetsuya, Bustin Michael
机构信息
Protein Section, Laboratory of Metabolism, National Cancer Institute (NCI), US National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nat Struct Mol Biol. 2006 Apr;13(4):305-10. doi: 10.1038/nsmb1077.
Abstract
The dynamic interaction of chromatin-binding proteins with their nucleosome binding sites is an important element in regulating the structure and function of chromatin in living cells. Here we review the major factors regulating the intranuclear mobility and chromatin binding of the linker histone H1, the most abundant family of nucleosome-binding proteins. The information available reveals that multiple and diverse factors modulate the interaction of H1 with chromatin at both a local and global level. This multifaceted mode of modulating the interaction of H1 with nucleosomes is part of the mechanism that regulates the dynamics of the chromatin fiber in living cells.
摘要
染色质结合蛋白与其核小体结合位点之间的动态相互作用是调节活细胞中染色质结构和功能的重要因素。在这里，我们综述了调节连接组蛋白H1（核小体结合蛋白中最丰富的家族）的核内移动性和染色质结合的主要因素。现有信息表明，多种不同因素在局部和全局水平上调节H1与染色质的相互作用。这种调节H1与核小体相互作用的多方面模式是调节活细胞中染色质纤维动态的机制的一部分。
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