Hegedus Z, Czibula A, Kiss-Toth E
Bioinformatics Group, Biological Research Centre, Szeged, Hungary.
Cell Mol Life Sci. 2006 Jul;63(14):1632-41. doi: 10.1007/s00018-006-6007-9.
Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several 'independent' signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.
识别细胞内第二信使系统的限速步骤或组成部分有望在病理条件下有效干扰这些信号通路。关于最近发现的一个名为tribbles的信号调节蛋白家族的新文献，为这些蛋白如何将几个“独立”的信号处理系统联系在一起提供了有趣的线索。通过其独特的作用方式，tribbles协调各种相互作用的信号通路的激活和抑制，因此在细胞应对环境挑战时似乎是决定细胞命运的关键。这篇综述总结了我们目前对tribbles功能的理解，并提供了关于各种tribbles基因的进化观点。
