细胞间黏附分子-1（ICAM-1）在桥本甲状腺炎的甲状腺上皮细胞上表达，但在格雷夫斯病或甲状腺乳头状癌中不表达。
Expression of intercellular adhesion molecule-1 (ICAM-1) on thyroid epithelial cells in Hashimoto's thyroiditis but not in Graves' disease or papillary thyroid cancer.
作者信息
Bagnasco M, Caretto A, Olive D, Pedini B, Canonica G W, Betterle C
机构信息
Istituto Scientifico di Medicina Interna, University of Genova, Italy.
出版信息
Clin Exp Immunol. 1991 Feb;83(2):309-13. doi: 10.1111/j.1365-2249.1991.tb05633.x.
Abstract
In order to study the possible role of antigen-independent adhesion systems in thyroid autoimmunity, we evaluated by indirect immunofluorescence the expression of lymphocyte functional antigen-1 (LFA-1) and its ligand ICAM-1 on mononuclear cell infiltrates (when present) and thyroid follicular cells of four patients with Hashimoto's thyroiditis, 30 with Graves' disease, five with papillary cancer, two with follicular adenoma, and two normal thyroid specimens. The expression of MHC class I and class II antigens was also evaluated. Most mononuclear infiltrates were LFA-1 positive, as expected. A positivity for ICAM-1 on follicular cells was observed in three out of four Hashimoto's thyroiditis specimens; such a phenomenon was totally absent in Graves' disease or any other pathological condition, or in normal tissue. MHC class II expression on thyrocytes was observed in all the patients with Hashimoto's thyroiditis, in 27 out of 30 with Graves' disease and in three out of five papillary cancer specimens.
摘要
为了研究抗原非依赖性黏附系统在甲状腺自身免疫中的可能作用，我们通过间接免疫荧光法评估了淋巴细胞功能相关抗原-1（LFA-1）及其配体细胞间黏附分子-1（ICAM-1）在4例桥本甲状腺炎患者、30例格雷夫斯病患者、5例乳头状癌患者、2例滤泡性腺瘤患者的单核细胞浸润（若存在）及甲状腺滤泡细胞上的表达情况，并评估了2例正常甲状腺标本。同时也评估了MHC I类和II类抗原的表达。如预期的那样，大多数单核浸润细胞LFA-1呈阳性。在4例桥本甲状腺炎标本中有3例观察到滤泡细胞ICAM-1呈阳性；而在格雷夫斯病或任何其他病理状态以及正常组织中均未出现这种现象。在所有桥本甲状腺炎患者、30例格雷夫斯病患者中的27例以及5例乳头状癌标本中的3例观察到甲状腺细胞上有MHC II类表达。
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