Calka O, Akdeniz N, Tuncer I, Metin A, Cesur R S
Department of Dermatology, Yüzüncü Yil University, Faculty of Medicine, Van, Turkey.
Clin Exp Dermatol. 2006 Jul;31(4):515-9. doi: 10.1111/j.1365-2230.2006.02132.x.
Pemphigus vulgaris (PV) is a rare autoimmune bullous skin disorder characterized by frequent involvement of the mucous membranes, usually beginning at the mouth.
To investigate the oesophageal involvement in patients with PV and to explore the primary relationship of the disease with symptoms such as dysphagia, odynophagia and retrosternal burning.
Oesophageal involvement was investigated by upper gastrointestinal endoscopy and biopsy during the early phase of the attacks in 26 patients with PV (12 men, 14 women, age range 24-63 years).
Histopathological examination and direct immunofluorescence of the oesophageal biopsy specimens revealed pemphigus involvement in 12 of 26 patients (46.15%).
The oesophagus is an important predilection zone for PV, thus care must be taken to detect these lesions at an early stage.
寻常型天疱疮（PV）是一种罕见的自身免疫性大疱性皮肤病，其特征是黏膜频繁受累，通常始于口腔。
研究PV患者的食管受累情况，并探讨该疾病与吞咽困难、吞咽痛和胸骨后烧灼感等症状之间的主要关系。
对26例PV患者（12例男性，14例女性，年龄范围24 - 63岁）在发作早期进行上消化道内镜检查和活检，以调查食管受累情况。
食管活检标本的组织病理学检查和直接免疫荧光显示，26例患者中有12例（46.15%）存在天疱疮累及。
食管是PV的一个重要受累部位，因此必须注意在早期检测这些病变。
