Marazziti Donatella, Dell'Osso Bernardo
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, 56100 Pisa, Italy.
Clin Pract Epidemiol Ment Health. 2006 May 22;2:9. doi: 10.1186/1745-0179-2-9.
Compulsive-Impulsive Sexual Behaviors (C-ISBs) include repetitive sexual acts and compulsive sexual thoughts which occur so frequently and with such intensity that they interfere with sexual intimacy and interpersonal and occupational functioning and whose categorization and effective treatments are still unclear. We report the case of a patient affected by C-ISBs and bipolar disorder of type II who improved dramatically after three months' addition of topiramate to citalopram. Topiramate is a powerful anticonvulsant which has recently been proposed also for the treatment of migraine, bipolar disorder and binge eating disorder. This case-report suggests that topiramate might be beneficial in augmentation with citalopram in patients suffering from C-ISBs, although controlled studies to confirm our findings are needed.
强迫-冲动性性行为（C-ISBs）包括重复性的性行为和强迫性的性想法，这些行为和想法出现得如此频繁且强度如此之大，以至于干扰了性亲密关系以及人际和职业功能，并且其分类和有效治疗方法仍不明确。我们报告了一例患有C-ISBs和II型双相情感障碍的患者，在西酞普兰基础上加用托吡酯三个月后病情显著改善。托吡酯是一种强效抗惊厥药，最近也被提议用于治疗偏头痛、双相情感障碍和暴饮暴食症。本病例报告表明，托吡酯与西酞普兰联合使用可能对患有C-ISBs的患者有益，尽管需要对照研究来证实我们的发现。
