Kazanjian Avedis, Gross Eleanore A, Grimes H Leighton
Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Crit Rev Oncol Hematol. 2006 Aug;59(2):85-97. doi: 10.1016/j.critrevonc.2006.02.002. Epub 2006 May 23.
The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood. Patients with mutations in Gfi1 exhibit severe congenital neutropenia (SCN) or non-immune chronic idiopathic neutropenia of adults. Gfi1 was initially described as an oncoprotein that mediates tumor progression in a mouse model of leukemia; however, recent data suggest that Gfi1 may act as either an oncogene or an anti-proliferative tumor suppressor gene depending on the cell type. Here we review the latest literature on Gfi1, and emphasize its role in the hematopoietic, sensory and neuroendocrine systems.
生长因子独立性-1（Gfi1）转录因子是神经内分泌细胞、感觉神经元和血液正常发育所必需的。Gfi1发生突变的患者表现出严重先天性中性粒细胞减少症（SCN）或成人非免疫性慢性特发性中性粒细胞减少症。Gfi1最初被描述为一种在白血病小鼠模型中介导肿瘤进展的癌蛋白；然而，最近的数据表明，根据细胞类型，Gfi1可能作为癌基因或抗增殖肿瘤抑制基因发挥作用。在此，我们综述了关于Gfi1的最新文献，并强调其在造血、感觉和神经内分泌系统中的作用。
