Jin Guo-Hua, Huang Zhen, Tan Xue-Feng, Tian Mei-Ling, Zhang Xin-Hua, Qin Jian-Bing, Xu Hui-Jun, Yew D T, Mak Y T
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Nantong University, Nantong 226001, China.
Cell Biol Int. 2006 Jun;30(6):500-4. doi: 10.1016/j.cellbi.2005.12.012. Epub 2006 May 23.
Extract of Ginkgo biloba (EGb) has been therapeutically used for several decades to increase peripheral and cerebral blood flow so as to prevent cardiovascular and neurovascular diseases. However, the role of EGb in neuroprotective effects has received much attention recently. In this study, we investigated the effect of EGb on the development of NOS and AChE positive neurons in the rat embryonic basal forebrain. The results showed that treated with EGb, the OD of MTT staining analysis, and the numbers, the cell sizes and circumferences of NOS and AChE positive neurons were greatly promoted. These data suggest that EGb had similar effects of the neurotrophins such as NGF and BDNF in promoting the development of NOS and AChE positive neurons in the rat embryonic basal forebrain.
