Alapetite C, Baroche C, Remvikos Y, Goubin G, Moustacchi E
Institut Curie, Section de Biologie, Paris, France.
Int J Radiat Biol. 1991 Feb;59(2):385-96. doi: 10.1080/09553009114550351.
The clonogenic cell survival to gamma-rays was determined in a human mammary epithelial cell line transfected by an activated ras oncogene in comparison to either the host untransfected cell line or the same cell line transfected by the neo gene. In contrast to previous observation of fibroblasts derived from a murine cellular system (NIH 3T3), the analysis of survival curves did not demonstrate an acquired radioresistance in the human ras transfected cells as opposed to the two other cell lines. In other words, the appearance of resistance to ionizing radiation does not seem to be a feature which can be generalized to all situations associated to activation of a specific oncogene (ras).
与宿主未转染细胞系或用新霉素基因转染的同一细胞系相比，在由活化的ras癌基因转染的人乳腺上皮细胞系中测定了对γ射线的克隆形成细胞存活率。与先前在源自鼠细胞系统（NIH 3T3）的成纤维细胞中的观察结果相反，存活曲线分析并未显示出与另外两个细胞系相比，人ras转染细胞获得了辐射抗性。换句话说，对电离辐射的抗性似乎并不是一个可以推广到与特定癌基因（ras）激活相关的所有情况的特征。
