Weickert M O, Pfeiffer A F H
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Diabetologia. 2006 Aug;49(8):1732-41. doi: 10.1007/s00125-006-0295-3. Epub 2006 May 23.
Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions.
脂肪肝和肝脏甘油三酯蓄积与肥胖、胰岛素抵抗及2型糖尿病密切相关，并受营养因素影响。肝脏对葡萄糖和脂质稳态的调节受激素、激素调节信号通路及转录因子组成的复杂系统影响。近来，在阐明胰岛素抵抗状态下受影响的分子途径和潜在因素方面取得了显著进展。在本综述中，我们讨论了一些参与肝脏葡萄糖和脂质代谢调节的关键因素。了解将肝脏脂质蓄积与葡萄糖代谢受损联系起来的分子网络，可能为饮食或药物干预提供靶点。
