Angwin Anthony J, Copland David A, Chenery Helen J, Murdoch Bruce E, Silburn Peter A
Centre for Research in Language Processing and Linguistics, University of Queensland, and Department of Neurosciences, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Neuropsychology. 2006 May;20(3):299-306. doi: 10.1037/0894-4105.20.3.299.
Research has suggested that semantic processing deficits in Parkinson's disease (PD) are related to striatal dopamine deficiency. As an investigation of the influence of dopamine on semantic activation in PD, 7 participants with PD performed a lexical-decision task when on and off levodopa medication. Seven healthy controls matched to the participants with PD in terms of sex, age, and education also participated in the study. By use of a multipriming paradigm, whereby 2 prime words were presented prior to the target word, semantic priming effects were measured across stimulus onset asynchronies (SOAs) of 250 ms and 1,200 ms. The results revealed a similar pattern of priming across SOAs for the control group and the PD participants on medication. In contrast, within-group comparisons revealed that automatic semantic activation was compromised in PD participants when off medication. The implications of these results for the neuromodulatory influence of dopamine on semantic processing in PD are discussed.
研究表明，帕金森病（PD）中的语义加工缺陷与纹状体多巴胺缺乏有关。作为对多巴胺对PD语义激活影响的一项研究，7名PD患者在服用左旋多巴药物和未服用时分别执行了词汇判断任务。7名在性别、年龄和教育程度上与PD患者匹配的健康对照者也参与了该研究。通过使用多启动范式，即在目标词之前呈现2个启动词，在250毫秒和1200毫秒的刺激起始异步时间（SOA）下测量语义启动效应。结果显示，对照组和服用药物的PD参与者在不同SOA下的启动模式相似。相比之下，组内比较显示，未服用药物的PD参与者的自动语义激活受到损害。本文讨论了这些结果对多巴胺对PD语义加工的神经调节影响的意义。
