Claflin Dragana Ivkovich, Buffington Michelle L
Department of Psychology, Wright State University, Dayton, OH 45434, USA.
Behav Neurosci. 2006 Apr;120(2):257-66. doi: 10.1037/0735-7044.120.2.257.
Recent studies of delay eyeblink conditioning (EBC) in young rats have demonstrated different effects of various conditioned and unconditioned stimulus (CS-US) preexposure conditions on learning at different ages. The present study extends this research to trace EBC. Subjects experienced 1 of 3 preexposure conditions (paired CS-US, unpaired CS-US, or no stimuli) at either 20 or 24 days of age. Four days later, they were conditioned using either trace (Experiment 1) or delay (Experiment 2) EBC parameters. Results were similar at both ages tested. Paired preexposure facilitated acquisition of delay but not trace relative to context preexposure. Unpaired preexposure impaired acquisition of both delay and trace. These behavioral findings provide a foundation for hypotheses about the functional maturation of cerebellar, hippocampal, and entorhinal learning circuits.
近期对幼鼠延迟眨眼条件反射（EBC）的研究表明，各种条件刺激和非条件刺激（CS-US）预暴露条件在不同年龄对学习有不同影响。本研究将这一研究扩展至痕迹EBC。实验对象在20日龄或24日龄时经历3种预暴露条件之一（配对CS-US、非配对CS-US或无刺激）。4天后，使用痕迹（实验1）或延迟（实验2）EBC参数对它们进行条件反射训练。在两个测试年龄的结果相似。相对于背景预暴露，配对预暴露促进了延迟条件反射的习得，但对痕迹条件反射无促进作用。非配对预暴露损害了延迟和痕迹条件反射的习得。这些行为学发现为关于小脑、海马体和内嗅学习回路功能成熟的假说提供了基础。
