Frye C A, Sumida K, Zimmerberg B, Brunelli S A
Department of Psychology, University at Albany, State University of New York, Albany, NY 12222, USA.
Behav Neurosci. 2006 Apr;120(2):281-9. doi: 10.1037/0735-7044.120.2.281.
Duration and intensity of lordosis is mediated by actions of the progesterone (P) metabolite, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha,5 alpha-THP) at GABA-sub(A) receptors in the midbrain ventral tegmental area. Because rats selectively bred for infantile vocalizations may differ in endogenous 3 alpha,5 alpha-THP secretion, their sexual behavior, midbrain, and plasma 3 alpha,5 alpha-THP levels as adult rats in behavioral estrus was examined. Rats bred for high rates of infantile vocalizations had shorter latencies and intervals between intromissions and ejaculation, higher lordosis quotients and ratings, more pacing of their sexual contacts, and had higher P and 3 alpha,5 alpha-THP levels in plasma and midbrain than did rats bred for low rats of infantile vocalizations. Thus, levels of 3 alpha,5 alpha-THP in the midbrain are associated with differences in sexual behavior of these rats.
脊柱前凸的持续时间和强度是由孕酮（P）代谢产物3α-羟基-5α-孕烷-20-酮（3α,5α-THP）作用于中脑腹侧被盖区的GABA-A受体介导的。由于选择性培育用于发出婴儿般叫声的大鼠在内源性3α,5α-THP分泌方面可能存在差异，因此对它们作为行为发情期成年大鼠的性行为、中脑和血浆3α,5α-THP水平进行了检查。培育用于发出高频率婴儿般叫声的大鼠在插入和射精之间的潜伏期和间隔更短，脊柱前凸商数和评分更高，性行为接触的节奏更快，并且与培育用于发出低频率婴儿般叫声的大鼠相比，其血浆和中脑中的P和3α,5α-THP水平更高。因此，中脑中3α,5α-THP的水平与这些大鼠性行为的差异有关。
