预防性抗生素对择期腹腔镜胆囊切除术后感染并发症的影响：一项前瞻性随机研究。
The impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study.
作者信息
Chang Wen-Tsan, Lee King-Teh, Chuang Shih-Chang, Wang Shen-Nien, Kuo Kung-Kai, Chen Jong-Shyone, Sheen Pai-Ching
机构信息
Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Taiwan.
出版信息
Am J Surg. 2006 Jun;191(6):721-5. doi: 10.1016/j.amjsurg.2006.01.050.
BACKGROUND
The aim of this prospective randomized study was to investigate the necessity and impact of prophylactic antibiotics on postoperative infection complications in elective laparoscopic cholecystectomy.
METHODS
At the time of induction of anesthesia, group A patients (n = 141) received 1 g cefazolin, and group B patients (control; n = 136) received 10 mL isotonic sodium chloride solution. Patients' characteristics and general operative outcomes were compared and analyzed.
RESULTS
The overall rate of infection was 1.1% for total 277 patients (0.7% for group A patients and 1.5% for group B patients). No significant difference in infection complications was found between these 2 groups. Also any risk factors contributing to infection complications could not be found.
CONCLUSIONS
We do not recommend the use of prophylactic antibiotics in elective laparoscopic cholecystectomy because they will not decrease the already-low rate of postoperative infectious complications.
背景
这项前瞻性随机研究的目的是探讨预防性抗生素在择期腹腔镜胆囊切除术中对术后感染并发症的必要性及影响。
方法
在麻醉诱导时，A组患者（n = 141）接受1克头孢唑林，B组患者（对照组；n = 136）接受10毫升等渗氯化钠溶液。对患者的特征和一般手术结果进行比较和分析。
结果
277例患者的总感染率为1.1%（A组患者为0.7%，B组患者为1.5%）。两组之间在感染并发症方面未发现显著差异。也未发现导致感染并发症的任何危险因素。
结论
我们不建议在择期腹腔镜胆囊切除术中使用预防性抗生素，因为它们不会降低本就较低的术后感染并发症发生率。
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