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腺病毒E1a基因产物对HER-2/c-erbB-2原癌基因表达的抑制作用。

Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.

作者信息

Yan D H, Chang L S, Hung M C

机构信息

Department of Tumor Biology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.

出版信息

Oncogene. 1991 Feb;6(2):343-5.

PMID:1672040
Abstract

The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.

摘要

腺病毒的E3区域通过内吞作用诱导表皮生长因子受体（EGFR）下调。在此我们报告，一种与EGFR相关的蛋白，即HER-2/c-erbB-2基因产物p185，也会被腺病毒下调，但通过不同的机制。我们发现腺病毒E1a基因在RNA水平上负责抑制HER-2/c-erbB-2。

相似文献

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Oncogene. 1991 Feb;6(2):343-5.
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