Alonso Ana, Fernández Rebeca, Moreno María, Ordóñez Patricia, González-Pardo Héctor, Conejo Nélida M, Díaz Fernando, González Celestino
Department of Functional Biology, Physiology Area, University of Oviedo, C/Julián Clavería s/n 33006, Oviedo, Spain.
J Gerontol A Biol Sci Med Sci. 2006 May;61(5):419-26. doi: 10.1093/gerona/61.5.419.
Aging is associated with insulin resistance, which represents a common factor in age-related diseases. We aimed to determine the role of 17beta-estradiol on insulin sensitivity and memory during aging using ovariectomized rats (2-26 months of age) treated with physiological doses of 17beta-estradiol. Our results indicate a lack of effect of 17beta-estradiol replacement on spatial memory assessed in a water maze. Conversely, estradiol treatment improved insulin sensitivity in aging rats. These data imply that relatively low doses of 17beta-estradiol may have beneficial effects on glucose homeostasis due to the protective effects of estrogen. However, estradiol treatment used in the present study did not prevent memory impairment associated with aging.
衰老与胰岛素抵抗相关，胰岛素抵抗是衰老相关疾病的一个共同因素。我们旨在利用接受生理剂量17β-雌二醇治疗的去卵巢大鼠（2至26月龄），确定17β-雌二醇在衰老过程中对胰岛素敏感性和记忆的作用。我们的结果表明，17β-雌二醇替代对水迷宫中评估的空间记忆没有影响。相反，雌二醇治疗改善了衰老大鼠的胰岛素敏感性。这些数据表明，由于雌激素的保护作用，相对低剂量的17β-雌二醇可能对葡萄糖稳态有有益影响。然而，本研究中使用的雌二醇治疗并未预防与衰老相关的记忆损害。
