精神分裂症中的载脂蛋白E基因型与气味识别

Apolipoprotein E genotype and odor identification in schizophrenia.

作者信息

Moberg Paul J, Arnold Steven E, Roalf David R, Balderston Catherine C, Abbazia Jaime, Kohler Christian G, Gur Raquel E, Turetsky Bruce I

机构信息

Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

出版信息

J Neuropsychiatry Clin Neurosci. 2006 Spring;18(2):231-3. doi: 10.1176/jnp.2006.18.2.231.

DOI:10.1176/jnp.2006.18.2.231

PMID:16720801

Abstract

The authors examined Apolipoprotein E (ApoE) genotype frequencies and unirhinal odor identification in 28 schizophrenia patients and 26 healthy comparison subjects. No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele.

摘要

作者对28名精神分裂症患者和26名健康对照者的载脂蛋白E（ApoE）基因型频率及单侧嗅觉识别能力进行了检测。在两个诊断组中均未观察到ApoE状态与嗅觉之间存在显著关联。作者得出结论，精神分裂症患者的嗅觉缺陷似乎并非由ApoE等位基因介导。