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本文引用的文献

1
Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis.间质性肺疾病是新诊断的多发性肌炎和皮肌炎的常见表现。
Ann Rheum Dis. 2004 Mar;63(3):297-301. doi: 10.1136/ard.2003.006122.
2
Serial chest CT findings in interstitial lung disease associated with polymyositis-dermatomyositis.多发性肌炎-皮肌炎相关间质性肺疾病的胸部CT系列表现
Eur J Radiol. 2004 Mar;49(3):235-44. doi: 10.1016/S0720-048X(03)00094-9.
3
Three cases of 'mechanic's hands' associated with interstitial pneumonia: possible involvement with foot lesions.三例与间质性肺炎相关的“机械工手”：可能累及足部病变。
J Dermatol. 2003 Dec;30(12):892-7. doi: 10.1111/j.1346-8138.2003.tb00344.x.
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Update on juvenile dermatomyositis: new advances in understanding its etiopathogenesis.青少年皮肌炎的最新进展：在理解其发病机制方面的新进展
Curr Opin Rheumatol. 2003 Sep;15(5):595-601. doi: 10.1097/00002281-200309000-00013.
5
Dermatomyositis and Polymyositis.
Curr Treat Options Neurol. 2003 Sep;5(5):349-356. doi: 10.1007/s11940-003-0025-9.
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Interstitial lung disease in polymyositis and dermatomyositis.多发性肌炎和皮肌炎中的间质性肺疾病。
Arthritis Rheum. 2002 Dec 15;47(6):614-22. doi: 10.1002/art.10794.
7
Rapidly progressive interstitial lung disease in a dermatomyositis patient with high levels of creatine phosphokinase, severe muscle symptoms and positive anti-Jo-1 antibody.一名皮肌炎患者出现快速进展性间质性肺疾病，伴有肌酸磷酸激酶水平升高、严重肌肉症状及抗Jo-1抗体阳性。
Intern Med. 2002 Jul;41(7):584-8. doi: 10.2169/internalmedicine.41.584.
8
[Interstitial lung diseases in polymyositis and dermatomyositis].[多发性肌炎和皮肌炎中的间质性肺疾病]
Rev Med Interne. 2001 Nov;22(11):1083-96. doi: 10.1016/s0248-8663(01)00473-8.
9
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver.胶原病中的肝脏：160例病例的病理学研究，特别提及肝动脉炎、原发性胆汁性肝硬化、自身免疫性肝炎和肝脏结节性再生性增生。
Liver. 2000 Oct;20(5):366-73. doi: 10.1034/j.1600-0676.2000.020005366.x.
10
Interstitial lung disease in polymyositis and dermatomyositis.多发性肌炎和皮肌炎中的间质性肺疾病。
Curr Opin Rheumatol. 2000 Nov;12(6):501-8. doi: 10.1097/00002281-200011000-00005.

重度幼年皮肌炎：两名患者合并有肌肉皮肤外受累。

Severe juvenile dermatomyositis: two patients complicated with extra musculocutaneous involvement.

作者信息

Tosun Ayşe, Serdaroğlu Gül, Aslan Mehmet Tayyip, Polat Muzaffer, Akalin Taner, Tekgul Hasan, Gökben Sarenur

机构信息

Division of Pediatric Neurology, Department of Pediatrics, Ege University Medical School, Bornova, Izmir 35100, Turkey.

出版信息

Rheumatol Int. 2006 Sep;26(11):1040-3. doi: 10.1007/s00296-006-0141-4. Epub 2006 May 24.

DOI:10.1007/s00296-006-0141-4
PMID:16721599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7102511/
Abstract

Here we report two patients with severe juvenile dermatomyositis (JDM) complicated with extra musculocutaneous involvement. The first case (a 10-year-old boy) had unusual initial presentation of JDM complicated with interstitial lung disease documented with high-resolution computed tomography. He had a rapidly progressive course and died in 7 weeks after the onset of the disease despite steroid and immunosuppressive treatment. The second case (a 14-year-old boy) was presented with myositis complicated with hepatitis. He also had a chronic course of JDM with unfavorable outcome. It appears that the prognosis of patients with severe JDM is related with the degree of autoimmune vasculitis on extra musculocutaneous involvement.

摘要

在此，我们报告两例患有严重青少年皮肌炎（JDM）并伴有肌肉皮肤外受累的患者。第一例（一名10岁男孩）JDM的初始表现不同寻常，高分辨率计算机断层扫描显示其合并间质性肺病。他病情进展迅速，尽管接受了类固醇和免疫抑制治疗，但在疾病发作后7周死亡。第二例（一名14岁男孩）表现为肌炎合并肝炎。他的JDM病程也呈慢性，预后不佳。看来，严重JDM患者的预后与肌肉皮肤外受累的自身免疫性血管炎程度有关。