Soyka M, Penning R, Wittchen U
Psychiatric Hospital, University of Munich, Munich, Germany.
Pharmacopsychiatry. 2006 May;39(3):85-7. doi: 10.1055/s-2006-941482.
Some recent studies have suggested a lower risk of fatal intoxications in drug-dependent patients under buprenorphine compared to methadone treatment.
Epidemiological reference data for the Munich region suggest that in 2003 approximately 10 % of all substitution patients were treated with buprenorphine, and 87 % with methadone. We studied the proportion of patients under methadone and buprenorphine substitution among drug-related deaths. Data from forensic post-mortem and toxicological analysis were analyzed.
Data indicate that in 96 (35 %) of all 272 so-called drug deaths, methadone was involved compared to a single case of buprenorphine, possibly indicating a relatively better risk profile of buprenorphine.
More prospective studies are necessary to assess the risk of fatal intoxications under different substitution regimens.
最近的一些研究表明，与美沙酮治疗相比，丁丙诺啡治疗的药物依赖患者致命中毒风险较低。
慕尼黑地区的流行病学参考数据表明，2003年所有替代治疗患者中约10%接受丁丙诺啡治疗，87%接受美沙酮治疗。我们研究了药物相关死亡中接受美沙酮和丁丙诺啡替代治疗的患者比例。对法医尸检和毒理学分析数据进行了分析。
数据表明，在所有272例所谓的药物死亡病例中，有96例（35%）涉及美沙酮，而涉及丁丙诺啡的仅有1例，这可能表明丁丙诺啡的风险状况相对较好。
需要更多前瞻性研究来评估不同替代治疗方案下致命中毒的风险。
