Harada K I, Yamamoto K, Saito T
Pharmacopsychiatry. 2006 May;39(3):113. doi: 10.1055/s-2006-941487.
Here we report on a patient with schizophrenia who suffered from medication-refractory coprophagia. Although there were few cases in which psychotropic medication was effective against coprophagia, we encountered a patient with schizophrenia in whom coprophagia rapidly disappeared after treatment with perospirone, a novel atypical antipsychotic drug of the serotonin-dopamine antagonist (SDA) type. Perospirone has a uniquely high affinity for serotonin-1A receptors, and it could be speculated that perospirone, as a serotonin-1A receptor agonist combined with SDA, may have greater efficacy for treatment-refractory symptoms of schizophrenia. Thus, perospirone is an agent with possible efficacy for medication-refractory schizophrenia.
在此，我们报告一例患有精神分裂症且存在难治性食粪症的患者。尽管很少有精神药物对食粪症有效的病例，但我们遇到了一名精神分裂症患者，在用新型非典型抗精神病药物——血清素 - 多巴胺拮抗剂（SDA）类型的哌罗匹隆治疗后，食粪症迅速消失。哌罗匹隆对血清素 - 1A受体具有独特的高亲和力，可以推测，作为血清素 - 1A受体激动剂与SDA结合的哌罗匹隆，可能对精神分裂症的难治性症状具有更大疗效。因此，哌罗匹隆是一种对难治性精神分裂症可能有效的药物。
