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[川芎嗪注射液对大鼠失血性休克复苏过程中淋巴循环的干扰作用]

[Interferential effect of ligustrazine injection on lymph circulation during the recovery of hemorrhagic shock in rats].

作者信息

Liu Yan-Kai, Zhang Xiao-Yun, Jiang Hua

机构信息

Hebei North University, Zhangjiakou 075029, China.

出版信息

Zhong Yao Cai. 2006 Jan;29(1):46-8.

Abstract

OBJECTIVE

To explore effects of ligustrazine injection (LI) on lymph circulation during the recovery of heamoregic shock.

METHODS

Effects of LI on lymph circulation were observed and determined in 16 Wistar rats by lymphatology methods.

RESULTS

During hemorrhagic shock, the intestinal lymph flux, lymphocytes out put was obviously decreased, and there was little monocytes in the lymph fluid, but the lymph fluid viscosity was increased. After treatment of LI, the intestinal lymph flux, lymphocytes out put was obviously increased, and there was a lot of monocytes in the lymph fluid. There were significant difference compared with control group (P < 0.01). Besides, LI could make the lymph fluid viscosity decrease and the effect was strong than that of control group (P < 0.01).

CONCLUSION

LI can intervene the recovery of heamoregic shock through enhaning the transport function of lymph circulation, the number of lymphocytes and monocytes, and decreasing lymph fluid viscosity.

摘要

目的

探讨川芎嗪注射液(LI)对失血性休克恢复过程中淋巴循环的影响。

方法

采用淋巴学方法观察并测定16只Wistar大鼠LI对淋巴循环的影响。

结果

失血性休克期间,肠淋巴流量、淋巴细胞输出明显减少,淋巴液中单核细胞很少,但淋巴液黏度增加。LI治疗后,肠淋巴流量、淋巴细胞输出明显增加,淋巴液中有大量单核细胞。与对照组相比有显著差异(P<0.01)。此外,LI可使淋巴液黏度降低,且作用强于对照组(P<0.01)。

结论

LI可通过增强淋巴循环的运输功能、淋巴细胞和单核细胞数量以及降低淋巴液黏度来干预失血性休克的恢复。

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