Rajesh Bhagavatheeswaran, Jayachandran Divakaran, Mohandas Govindan, Radhakrishnan Kurupath
R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
J Altern Complement Med. 2006 May;12(4):367-71. doi: 10.1089/acm.2006.12.367.
The objective was to assess the efficacy of a yoga meditation protocol (YMP) as an adjunctive treatment in patients with drug-resistant chronic epilepsy.
The design was a prospective, nonrandomized, open-label, add-on trial with a 12-week baseline period, followed by a 12-week supervised YMP administration phase. The frequency of complex partial seizures (CPS) was assessed at 3, 6, and 12 months of the treatment period.
The setting was a comprehensive epilepsy care center attached to a tertiary referral medical institution situated on the southwest coast of the Indian peninsula.
The subjects were 20 patients (14 males and 6 females, age range 15 to 47 years, median 27 years) with unequivocally established diagnoses of epilepsy with at least 4 CPS (with or without secondary generalization) during the preceding 3 months.
Intervention consisted of a YMP 20 minutes twice daily (mornings and evenings) at home, and supervised sessions of a YMP every week for 3 months. Continuation of the YMP beyond 3 months was optional.
The outcome measure was the seizure frequency at 3, 6, and 12 months of the treatment period. The subjects with > or = 50% reduction in monthly seizure rate from baseline were classified as responders, and subjects with <50% seizure reduction as nonresponders.
At 3 months, a reduction in seizure frequency was noted in all except 1 patient, six of whom had > or = 50% seizure reduction. Of 16 patients who continued the YMP beyond 3 months, 14 patients responded at 6 months; 6 of them were seizure-free for 3 months. All eight patients who continued the YMP beyond 6 months responded; three of them were seizure free for 6 months.
If confirmed through randomized trials involving a larger number of patients, this YMP may become a cost-effective and adverse effect-free adjunctive treatment in patients with drug-resistant epilepsies.
评估瑜伽冥想方案（YMP）作为耐药性慢性癫痫患者辅助治疗的疗效。
本研究为前瞻性、非随机、开放标签、附加试验，有12周的基线期，随后是12周的YMP监督给药阶段。在治疗期的3、6和12个月时评估复杂部分性发作（CPS）的频率。
研究地点是位于印度半岛西南海岸的一家三级转诊医疗机构附属的综合癫痫护理中心。
受试者为20例患者（14例男性和6例女性，年龄范围15至47岁，中位数27岁），明确诊断为癫痫，在过去3个月内至少有4次CPS发作（有或无继发性全身性发作）。
干预包括在家中每天两次（早上和晚上）进行20分钟的YMP，以及每周进行一次YMP监督课程，持续3个月。3个月后是否继续进行YMP可自行选择。
观察指标为治疗期3、6和12个月时的癫痫发作频率。每月癫痫发作率较基线降低≥50%的受试者被分类为反应者，癫痫发作减少<50%的受试者为无反应者。
在3个月时，除1例患者外，所有患者的癫痫发作频率均有所降低，其中6例患者癫痫发作减少≥50%。在3个月后继续进行YMP的16例患者中，14例患者在6个月时有反应；其中6例患者有3个月无癫痫发作。在6个月后继续进行YMP的所有8例患者均有反应；其中3例患者有6个月无癫痫发作。
如果通过涉及更多患者的随机试验得到证实，这种YMP可能成为耐药性癫痫患者具有成本效益且无不良反应的辅助治疗方法。
