Enoch Stuart, Kupitz Susanne, Miller David R, Harding Keith G
Wound Healing Research Unit, Cardiff University, Medicentre, Cardiff, UK.
Int Wound J. 2005 Jun;2(2):142-7. doi: 10.1111/j.1742-4801.2005.00096.x.
Despite advances in molecular biology and a repertoire of other therapeutic options, chronic venous leg ulcers remain a significant problem within our society. There are various reasons, both local and systemic, which contribute to the non healing nature of such wounds. Among them, dystrophic calcification (DC) or calcified deposits within the ulcer bed, although rare, is an overlooked and a seldom reported cause. In the presence of DC, wound healing cannot proceed through a timely and orderly manner resulting in a non healing ulcer. In this article, we discuss the aetiology, pathophysiology and the management options of this rarely reported condition. We also report their clinical prognosis using a series of patients with venous ulcers complicated by DC leading to difficulties in healing.
尽管分子生物学取得了进展且有一系列其他治疗选择,但下肢慢性静脉溃疡在我们的社会中仍然是一个重大问题。导致此类伤口不愈合的原因有多种,包括局部和全身因素。其中,营养不良性钙化(DC)或溃疡床内的钙化沉积虽然罕见,但却是一个被忽视且很少报道的原因。在存在DC的情况下,伤口愈合无法及时、有序地进行,导致溃疡不愈合。在本文中,我们讨论了这种罕见病症的病因、病理生理学和管理选择。我们还报告了一系列合并DC导致愈合困难的静脉溃疡患者的临床预后。