Lawrence Bonnie M, Snyder Lawrence H
Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA.
J Neurophysiol. 2006 Sep;96(3):1393-400. doi: 10.1152/jn.01368.2005. Epub 2006 May 24.
We previously demonstrated that the activities of neurons in the lateral intraparietal area (LIP) and the parietal reach region (PRR) of the posterior parietal cortex (PPC) are modulated by nonspatial effector-specific information. We now report similar modulation in FEF, an area of frontal cortex that is reciprocally connected with LIP. Although it is possible that these effector-specific signals originate in LIP and are conveyed to FEF, it is also possible that these signals originate in FEF and are "fed back" to LIP. We found that signal magnitude was no larger, and onset time no earlier, in FEF compared with LIP. Moreover, effector-specific activity in FEF, but not in LIP, was largely driven by spatial prediction. These results suggest that the saccade-related effector-specific signals found in LIP do not originate in FEF. Conversely, LIP may contribute to the effector-specific signals found in FEF, but does not wholly account for them.
我们之前证明，顶叶后皮质（PPC）的侧顶内区（LIP）和顶叶够物区（PRR）中神经元的活动受非空间效应器特异性信息的调节。我们现在报告，在额叶眼动区（FEF，与LIP相互连接的额叶皮质区域）也存在类似的调节。虽然这些效应器特异性信号有可能起源于LIP并传递至FEF，但也有可能起源于FEF并“反馈”至LIP。我们发现，与LIP相比，FEF中的信号幅度并不更大，起始时间也不更早。此外，FEF中的效应器特异性活动很大程度上由空间预测驱动，而LIP中则不然。这些结果表明，在LIP中发现的与扫视相关的效应器特异性信号并非起源于FEF。相反，LIP可能对在FEF中发现的效应器特异性信号有贡献，但并不能完全解释这些信号。
