Kurishita A, Katoh H, Uehara Y, Uchida A, Mizutani Y, Ono T, Hirose S, Okada S
Radiation Biology Center, Kyoto University, Japan.
Int J Radiat Biol. 1991 Mar;59(3):711-6. doi: 10.1080/09553009114550621.
The radioprotective effect of OK432, a Streptococcus haemolyticus preparation, on bone marrow death was examined in mice. The LD50 value was increased from 7.55 Gy in controls to 8.45 Gy in mice treated once with OK432 immediately after irradiation. Multiple administrations of the agent further elevated the LD50 value to 9.56 Gy. The radioprotective effect was also apparent when multiple treatments were commenced as late as 72 h after irradiation.
研究了溶血链球菌制剂OK432对小鼠骨髓死亡的辐射防护作用。对照组的半数致死剂量（LD50）值为7.55 Gy，而在照射后立即单次给予OK432的小鼠中，LD50值增加到8.45 Gy。多次给予该制剂可使LD50值进一步提高到9.56 Gy。当在照射后72小时才开始多次治疗时，辐射防护作用也很明显。
