用于全生物体分析的蛋白质组芯片。

Proteome chips for whole-organism assays.

作者信息

Kung Li A, Snyder Michael

机构信息

Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06511, USA.

出版信息

Nat Rev Mol Cell Biol. 2006 Aug;7(8):617-22. doi: 10.1038/nrm1941. Epub 2006 May 24.

DOI:10.1038/nrm1941

PMID:16723973

Abstract

Over the past 5 years, protein-chip technology has emerged as a useful tool for the study of many kinds of protein interactions and biochemical activities. The construction of Saccharomyces cerevisiae whole-proteome arrays has enabled further studies of such interactions in a proteome-wide context. Here, we explore some of the recent advances that have been made at the '-omic' level using protein microarrays.

摘要

在过去5年里，蛋白质芯片技术已成为研究多种蛋白质相互作用和生化活性的有用工具。酿酒酵母全蛋白质组阵列的构建使得在全蛋白质组范围内对这类相互作用进行进一步研究成为可能。在此，我们探讨利用蛋白质微阵列在“组学”水平上取得的一些最新进展。