Collado Manuel, Serrano Manuel
Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Nat Rev Cancer. 2006 Jun;6(6):472-6. doi: 10.1038/nrc1884.
Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant neoplastic lesions, whereas they are scarce in malignant tumours. This association of senescence with the premalignant stages of tumour progression opens the possibility of using senescence markers as diagnostic and prognostic tools. Moreover, some chemotherapeutic protocols induce senescence in tumour cells and, consequently, senescence markers could help to monitor treatment response.
最近的研究表明，癌基因诱导的衰老（OIS）发生在肿瘤发生的早期阶段。衰老的肿瘤细胞在癌前肿瘤病变中大量存在，而在恶性肿瘤中则很少见。衰老与肿瘤进展的癌前阶段之间的这种关联为使用衰老标志物作为诊断和预后工具提供了可能性。此外，一些化疗方案可诱导肿瘤细胞衰老，因此，衰老标志物有助于监测治疗反应。
