FR209602及相关化合物，来自738号火山口状毛壳菌的新型抗真菌脂肽。I. 分类学、发酵、分离及理化性质
FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738. I. Taxonomy, fermentation, isolation and physico-chemical properties.
作者信息
Kanasaki Ryuichi, Sakamoto Kazutoshi, Hashimoto Michizane, Takase Shigehiro, Tsurumi Yasuhisa, Fujie Akihiko, Hino Motohiro, Hashimoto Seiji, Hori Yasuhiro
机构信息
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan.
出版信息
J Antibiot (Tokyo). 2006 Mar;59(3):137-44. doi: 10.1038/ja.2006.20.
Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleophoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.
新型抗真菌脂肽FR209602、FR209603和FR209604是从编号为738的真菌菌株发酵液中分离得到的，该菌株经形态学和生理学特征鉴定为杯状鞘孢菌。通过溶剂萃取、HP-20、YMC-ODS和硅胶柱色谱法以及冻干法对这些抗生素进行了纯化。这些化合物在结构上与我们之前报道的FR901379相似，后者在环肽部分有一个硫酸根残基。
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