FR901469，一种源自未鉴定真菌No.11243的新型抗真菌抗生素。I. 分类学、发酵、分离、理化性质及生物学特性

FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.

作者信息

Fujie A, Iwamoto T, Muramatsu H, Okudaira T, Nitta K, Nakanishi T, Sakamoto K, Hori Y, Hino M, Hashimoto S, Okuhara M

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 2000 Sep;53(9):912-9. doi: 10.7164/antibiotics.53.912.

DOI:10.7164/antibiotics.53.912

PMID:11099224

Abstract

FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182 approximately 187 degrees C and possesses the molecular formula C71H116N14O23. This compound has good water solubility. FR901469 inhibited the activity of 1,3-beta-glucan synthase from Candida albicans with an IC50 value of 0.05 microg/ml, and displayed greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.

摘要

FR901469是一种由未知真菌11243号产生的新型抗真菌抗生素。该化合物通过溶剂萃取、HP - 20和YMC ODS凝胶柱色谱法以及冻干从培养液中分离得到。FR901469是一种白色粉末，熔点约为182至187摄氏度，分子式为C71H116N14O23。该化合物具有良好的水溶性。FR901469抑制白色念珠菌1,3 - β - 葡聚糖合酶的活性，IC50值为0.05微克/毫升，并且比其他1,3 - β - 葡聚糖合酶抑制剂如WF11899A、棘白菌素B、刺囊霉素A和丘疹霉素B显示出更强的抑制活性。