Petteway S R, Lambert D M, Metcalf B W
Department of Antiinfectives, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
Trends Pharmacol Sci. 1991 Jan;12(1):28-34. doi: 10.1016/0165-6147(91)90485-b.
Infection of the T lymphocyte with HIV results in a cytopathic effect and cell death that has been linked to a selective loss of the helper T-lymphocyte function of the immune system. In addition to acute infection, which leads to cell death, a chronic or persistent infection also occurs. The persistence of these viral reservoirs has been implicated in the progression of HIV infection and AIDS. Rational drug discovery targeted to late-stage events in HIV replication has the potential to yield antiviral agents capable of blocking virus spread by inhibiting the production of infectious virions from these chronic reservoirs. Steve Petteway and colleagues discuss antiviral strategies that target the chronically infected cell, with a focus on HIV protease inhibitors.
HIV感染T淋巴细胞会导致细胞病变效应和细胞死亡，这与免疫系统辅助性T淋巴细胞功能的选择性丧失有关。除了导致细胞死亡的急性感染外，还会发生慢性或持续性感染。这些病毒储存库的持续存在与HIV感染和艾滋病的进展有关。针对HIV复制后期事件的合理药物研发有可能产生能够通过抑制这些慢性储存库中感染性病毒粒子的产生来阻断病毒传播的抗病毒药物。史蒂夫·佩特韦及其同事讨论了针对慢性感染细胞的抗病毒策略，重点是HIV蛋白酶抑制剂。
